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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
Molecularly imprinted TiO(2) thin film using stable ground-state complex as template as applied to selective
Zhihang Liu1, Shuangyan Huan, Jianhui Jiang
1State Key Laboratory of Chemo/Biosensing and Chemometrics, Chemistry and Chemical Engineering College, Department of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China.
Abstract:
Molecular recognition sites for mercury ions were imprinted in TiO(2) film using stable ground-state complex of 1-amino-8-naphtol-3,6-disodium sulfonate (ANDS) and mercury ions as template. The complex ratio between mercury ions and ANDS was estimated to be 2:1. Compared with the controlled and pure TiO(2) electrodes, the imprinted electrode revealed selectivity towards the imprinted ions. Linear calibration plots for mercury ions were obtained and the regression equation was I(p) (muA)=4.29x10(-7)+19.40 [Hg(2+)] with a detection limit of 3.06x10(-9)mol/l. The imprinted electrode could be used for more than 1 month. Recoveries were calculated at both high and low concentrations, with a mean recovery of 99.6%.
