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Published on: May 17, 2024
Is it time to treat prehypertension?
Dimitris P Papadopoulos1, Thomas K Makris, Vasilios Papademetriou
1Hypertension Clinic, Department of Cardiology, Laiko Hospital, 39 Karneadou Street, Athens, Greece. jimpapdoc@yahoo.com
Summary
Prehypertension, a blood pressure stage, affects 30% of adults and increases cardiovascular risk. Angiotensin receptor blockade (ARB) medication was shown to slow blood pressure increases in prehypertensive individuals.
Area of Science:
- Cardiology
- Public Health
- Pharmacology
Background:
- Prehypertension (120-139/80-89 mmHg) is prevalent (30% of adults) and elevates cardiovascular event risk.
- It is often linked with other cardiovascular risk factors.
- Current management relies on lifestyle changes, which are not always effective.
Purpose of the Study:
- To review pharmacologic intervention options for prehypertension.
- To focus on the results of the Trial of Preventing Hypertension (TROPHY).
Main Methods:
- The review discusses pharmacologic interventions for prehypertension.
- It specifically examines the findings of the TROPHY trial.
Main Results:
- The TROPHY trial is the first study on pharmacologic intervention for prehypertension.
- Angiotensin receptor blockade (ARB) was demonstrated to slow age-related blood pressure increases in prehypertensive patients.
Conclusions:
- Pharmacologic interventions, such as ARBs, offer a potential strategy for managing prehypertension.
- Further research may clarify the long-term prognosis and cost-effectiveness of these interventions.
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