Related Experiment Video

Updated: Jun 28, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
08:21

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

Renal handling of matrix Gla-protein in humans with moderate to severe hypertension

Roger J M W Rennenberg1, Leon J Schurgers, Cees Vermeer

  • 1Department of Internal Medicine, University Hospital Maastricht and Cardiovascular Research Institute Maastricht(CARIM), P. Debyelaan 25, Maastricht, The Netherlands. rre@sint.azm.nl

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|October 31, 2008
PubMed

Insights

Hypertension patients

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Vascular calcifications are frequent in hypertensive individuals.
  • Matrix Gla-protein (MGP) is a vitamin K-dependent protein crucial for inhibiting arterial calcification.
  • Reduced renal function is common in hypertension, potentially affecting MGP clearance.

Purpose of the Study:

  • To investigate the renal clearance of matrix Gla-protein (MGP) in hypertensive patients.
  • To assess the relationship between creatinine clearance and MGP renal extraction.
  • To determine if renal artery stenosis impacts MGP clearance.

Main Methods:

  • Ninety hypertensive patients undergoing renal angiography were studied.
  • Renal arterial and venous blood samples were collected to measure MGP levels.
  • Single kidney and total renal clearance of MGP were calculated.

Main Results:

  • The average renal fractional extraction of matrix Gla-protein was 12.8%.
  • No significant correlation was found between creatinine clearance and MGP fractional extraction.
  • Renal artery stenosis did not affect MGP extraction.

Conclusions:

  • The kidneys consistently extract matrix Gla-protein from plasma in hypertensive subjects.
  • MGP clearance by the kidneys is independent of renal function within the studied range.
  • These findings suggest a stable renal handling of MGP in hypertension.

More Related Videos

A Murine Model of Hemodialysis Access-Related Hand Dysfunction08:39

A Murine Model of Hemodialysis Access-Related Hand Dysfunction

Published on: May 31, 2022

Fabricating a Kidney Cortex Extracellular Matrix-Derived Hydrogel08:23

Fabricating a Kidney Cortex Extracellular Matrix-Derived Hydrogel

Published on: October 13, 2018

Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...