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Updated: Jun 28, 2026
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Coronoid-Temporalis Pedicled Flap for Orbital Floor Defect Reconstruction
Published on: December 5, 2025
Orbital floor reconstruction using porcine small intestinal submucosa
Peter E Seymour1, Howard M Krein, Douglas D Leventhal
1Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA. peterseymour2003@yahoo.com
Summary
Surgisis ES effectively supported orbital content in rabbit orbital floor fracture repair. While healing occurred, its role in promoting bone regeneration requires further investigation for human applications.
Area of Science:
- Biomaterials Science
- Ophthalmology
- Regenerative Medicine
Background:
- Orbital floor fractures are common in facial trauma.
- Current repair methods aim to restore orbital volume and function.
- Surgisis ES is a novel biomaterial for tissue regeneration.
Purpose of the Study:
- To evaluate Surgisis ES for orbital floor fracture repair in a rabbit model.
- To assess orbital content support and tissue regeneration.
- To compare Surgisis ES repair with natural healing.
Main Methods:
- Prospective, controlled, blinded pilot study in ten rabbits.
- Induced bilateral orbital floor fractures (5mm).
- Transconjunctival implantation of Surgisis ES in one orbit, contralateral as control. Histological analysis at 1, 3, and 12 months.
Main Results:
- No surgical complications (infection, entrapment, rejection) observed.
- Gross orbital appearance was similar between groups.
- Histology showed subtle differences: eosinophilic infiltrates and fibrosis in Surgisis ES sites, absent in controls. Both sites healed.
- Absence of foreign body giant cell reaction noted.
Conclusions:
- Surgisis ES demonstrates potential as a graft for orbital floor fracture repair.
- Its efficacy in promoting central bone regeneration remains unconfirmed.
- Further research is warranted for human orbital trauma applications.
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- Main_Methods
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