Recurrent respiratory infections: why not talking about it any more?
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Updated: Jun 28, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
E Nencioni1, E Chiappini, A Liguori
1Department of Pediatrics, University of Florence, Italy.
Insights
Recurrent respiratory infections (RRIs) in children are typically benign and self-limiting. Diagnosis relies on medical history and examination, avoiding unnecessary antibiotics and interventions like cough syrups.
Area of Science:
- Pediatrics
- Immunology
- Infectious Diseases
Background:
- Recurrent respiratory infections (RRIs) affect approximately 6% of schoolchildren.
- RRIs are generally benign with mild, postinfective immune system changes.
- Misdiagnosis can lead to unnecessary investigations and antibiotic treatments.
Purpose of the Study:
- To provide guidance on the diagnosis and management of RRIs in children.
- To differentiate benign RRIs from underlying serious conditions.
- To emphasize appropriate diagnostic and therapeutic strategies.
Main Methods:
- Review of clinical presentation and diagnostic approaches for RRIs.
- Evaluation of laboratory tests for excluding underlying diseases.
- Assessment of environmental risk factors and treatment interventions.
Main Results:
- Medical history and clinical examination are usually sufficient for diagnosing RRIs.
- Complete blood count and immunoglobulin levels can exclude specific immune deficiencies.
- Reducing environmental tobacco smoke and delaying daycare enrollment decrease RRIs.
Conclusions:
- Most RRIs are self-limited, and parents should be reassured.
- Antibiotic treatment and anti-cough syrups are not justified for RRIs.
- Nasal saline lavage and blowing are the only recommended interventions; surgery is reserved for specific indications.
Abstract:
Recurrent respiratory infections (RRIs) are a common and benign condition affecting about 6% of schoolchildren. Only mild, likely postinfective, modifications of the immune system have been proven, and parents should be reassured that the condition is self-limited. Nevertheless, if not correctly diagnosed, children may undergo several unnecessary investigations and multiple antibiotic courses. On the other hand, in some cases, efforts should be made to identify promptly possible underlying disease, including congenital or acquired immunodeficiency, vascular or airways malformation, tuberculosis, cystic fibrosis, or immotile-cilia syndrome. Careful medical history and clinical examination are usually sufficient to distinguish RRIs and no further research is generally needed. In uncertain cases a complete blood count with differential and the evaluation of total immunoglobulin serum levels are sufficient to exclude neutropenia, T- or B-lymphocyte defects, and selective IgA deficiency. It is essential to observe environmental risk factors: reducing environmental tobacco smoke at home is a fundamental goal and the postponed enrolment of children at day-care centres reduces the risk of RRIs. Antibiotic treatment are not justified since they do not shorten the course of the condition or prevent complications. Use of anti-cough syrups should be avoided. Nasal lavage with saline serum and the blowing are the only justified interventions. Adenoidectomy and tonsillectomy should be planned only in conditions included in validated guidelines.
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