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Updated: Jun 28, 2026
Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
CD226 Gly307Ser association with multiple autoimmune diseases
J P Hafler1, L M Maier, J D Cooper
1Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK. jason.hafler@cimr.cam.ac.uk
The CD226 gene variant rs763361/Gly307Ser is strongly associated with type 1 diabetes (T1D) susceptibility. This immune gene variant also shows evidence of association with multiple sclerosis (MS), autoimmune thyroid disease (AITD), and rheumatoid arthritis (RA).
Area of Science:
- Immunogenetics
- Human Genetics
- Autoimmune Diseases
Background:
- Genome-wide association studies (GWAS) identify genes and pathways for complex diseases.
- Shared variants among autoimmune disorders suggest common etiological mechanisms.
- Previous work linked CD226 SNP rs763361/Gly307Ser to type 1 diabetes (T1D) susceptibility.
Purpose of the Study:
- To identify the causal variant for T1D susceptibility within the CD226 gene.
- To investigate the association of CD226 variants with other autoimmune diseases, including multiple sclerosis (MS), autoimmune thyroid disease (AITD), and rheumatoid arthritis (RA).
Main Methods:
- Exonic resequencing and tag SNP mapping of the 18q22 region.
- Analysis of newly available samples for T1D, AITD, MS, and RA.
- Statistical association testing for the rs763361/Gly307Ser polymorphism.
Main Results:
- Strong support for the association of the Ser(307) allele of rs763361 with T1D (P=3.46 x 10(-9)).
- Evidence for association of Gly307Ser with MS (P=4.20 x 10(-4)) and RA (P=0.017).
- Continued potential evidence for association with AITD (P=0.0345).
Conclusions:
- The Ser(307) allele of rs763361 in CD226 predisposes individuals to T1D and MS.
- This variant may also contribute to AITD and RA susceptibility.
- rs763361 is a potential causal variant for these autoimmune conditions.
