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Updated: Jun 28, 2026
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Published on: July 11, 2013
Severe acneiform eruption induced by cetuximab (Erbitux)
Jung Eun Lee1, Sang Ju Lee, Hee Jung Lee
1Yonsei Star Skin & Laser Clinic, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Medical Journal
|October 31, 2008
Summary
Cetuximab, a cancer therapy targeting epidermal growth factor receptor, can cause severe acneiform eruptions. This case report details such an adverse event in a patient with colorectal cancer.
Area of Science:
- Oncology
- Dermatology
- Pharmacology
Background:
- Epidermal growth factor (EGF) regulates keratinocyte proliferation and cancer cell survival.
- Cetuximab is a monoclonal antibody targeting the epidermal growth factor receptor (EGFR).
- Cetuximab enhances tumor sensitivity to cancer treatments but can cause adverse events.
Observation:
- A 56-year-old man with colorectal cancer and liver metastases was treated with cetuximab.
- The patient developed a severe acneiform eruption.
Findings:
- Cetuximab-induced acneiform eruption is a significant adverse event.
- This adverse event requires clinical attention and management.
Implications:
- Understanding cetuximab's side effects is crucial for patient care.
- Managing dermatological adverse events can improve treatment adherence.
- Further research into mitigating cetuximab-induced skin reactions is warranted.
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