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Updated: Jun 28, 2026

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
[Lacosamide. A new antiepileptic drug as adjunctive therapy in patients with partial-onset seizures]
1Redaktion Medizinische Monatsschrift für Pharmazeuten, Birkenwaldstr 44, 70191 Stuttgart. tsaussele@deutscher-apotheker-verlag.de
Abstract:
Lacosamide (Vimpat) is an aniepileptic drug with a new, dual mode of action. Lacosamide enhances slow inactivation of voltage-gated sodium channels and modulates the collapsin response mediator protein-2 (CRMP-2), a protein, which is part of neuronal signal transduction pathways and which is attributed to neuroprotection. Reduction of seizure frequency could be demonstrated in several clinical studies in patients with partial-onset seizures who received lacosamide in addition to other antiepileptic drugs.
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