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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
E-selectin and L-selectin polymorphisms in patients with periodontitis
B Houshmand1, A Rafiei, M Hajilooi
1Department of Periodontology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
Journal of Periodontal Research
|November 1, 2008
Summary
The E-selectin Ser128Arg gene variant is linked to increased periodontitis risk in Iranian individuals. This genetic factor may influence susceptibility to this common gum disease.
Area of Science:
- Genetics
- Periodontology
- Molecular Biology
Background:
- Periodontitis is a complex disease influenced by genetic and environmental factors.
- Genetic variations in adhesion molecule genes may affect individual susceptibility.
- Polymorphisms in E-selectin and L-selectin genes are investigated for their role in periodontitis.
Purpose of the Study:
- To investigate the genetic association between E-selectin Ser128Arg and L-selectin Phe206Leu polymorphisms and periodontitis.
- To determine if specific gene variants increase the risk of developing periodontitis.
Main Methods:
- DNA was extracted from whole blood samples of 88 periodontitis patients and 139 healthy controls.
- Genotyping for E-selectin Ser128Arg and L-selectin Phe206Leu polymorphisms was performed using polymerase chain reaction with sequence-specific primers.
Main Results:
- A significant association was found between the E-selectin Ser128Arg polymorphism and periodontitis.
- The 128Arg allele was more prevalent in periodontitis patients (31.25%) compared to controls (12.2%).
- The 128Arg allele increased the odds of periodontitis by 2.9 times (95% CI: 1.75-4.4).
- No significant association was observed for the L-selectin Phe206Leu polymorphism or between polymorphisms and disease subgroups.
Conclusions:
- The E-selectin Ser128Arg polymorphism may contribute to periodontitis susceptibility in the Iranian population.
- This genetic variant could be a risk factor for developing periodontitis.
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