Related Experiment Video

Updated: Jun 28, 2026

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
11:14

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

Pregnancy outcomes in young women with perinatally acquired human immunodeficiency virus-1

Shauna F Williams1, Megan H Keane-Tarchichi, Linda Bettica

  • 1Department of Obstetrics, Gynecology, and Women's Health, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ 07101, USA.

American Journal of Obstetrics and Gynecology
|November 1, 2008
PubMed

Insights

Pregnancy outcomes for adolescents with perinatal human immunodeficiency virus (HIV) infection were reviewed. Despite complications, perinatal outcomes were favorable, with only one infant infected with HIV.

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Pediatrics

Background:

  • Perinatal human immunodeficiency virus (HIV) infection presents unique challenges in adolescent pregnancies.
  • Understanding pregnancy and neonatal outcomes is crucial for optimizing care.

Purpose of the Study:

  • To review pregnancy and neonatal outcomes among perinatally HIV-infected pregnant adolescents at a single institution.
  • To identify common comorbidities and obstetrical complications in this population.

Main Methods:

  • Retrospective review of maternal and neonatal records for 10 perinatally HIV-infected adolescents (1997-2007).
  • Data abstracted included demographics, HIV viral load and CD4 counts, antiretroviral therapy, comorbidities, pregnancy outcomes, and neonatal HIV status.

Main Results:

  • The median age at first pregnancy was 18.5 years; 80% had cervical dysplasia/STIs, and 70% had hematologic abnormalities.
  • Common complications included preterm delivery (31%) and preeclampsia (23%). Cesarean delivery rate was 62%, primarily for HIV indication.
  • One infant (10%) acquired HIV infection; all infants were born alive.

Conclusions:

  • Perinatal outcomes for adolescents with HIV were favorable despite high rates of STIs, cesarean delivery, preterm birth, and hypertensive disorders.
  • Effective management strategies can lead to positive maternal and neonatal health outcomes in this population.
Abstract

More Related Videos

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets08:12

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets

Published on: September 6, 2019

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection08:15

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Published on: January 31, 2020

Related Concept Videos

Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Inhibitors of Virion Maturation and Assembly01:19

Inhibitors of Virion Maturation and Assembly

As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...