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Updated: Jun 28, 2026
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Estradiol valerate as a possible endocrine reproductive disruptor: evidence from an in vivo rat model
Daniel S Seidman1, Alek Itsekson, Michael Alesker
1Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, both affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. dseidman@post.tau.ac.il
Abstract:
We used an in vivo rat model to demonstrate that low-dose intradermal exposure to E(2) valerate has an inverse effect on the female's estrus cycle pattern and can significantly reduce litter size. These results suggest that, under certain circumstances, environmental exposure to exogenous estrogens may play a role as an endocrine disruptor and adversely affect reproductive outcome.
