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Related Concept Videos

Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...

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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

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Published on: May 1, 2015

Lymphatic differentiation in renal angiomyolipomas.

Stephen M Bonsib1, Mana Moghadamfalahi, Ami Bhalodia

  • 1Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA. sbonsi@lsuhsc.edu

Human Pathology
|November 1, 2008
PubMed
Summary

Lymphatic differentiation is common in renal angiomyolipomas, particularly in the smooth muscle areas. This finding expands our understanding of the mesenchymal potential of these kidney tumors.

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Murine Bilateral Renal Lymphadenectomy
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Murine Bilateral Renal Lymphadenectomy
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Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

Area of Science:

  • Nephrology
  • Pathology
  • Vascular Biology

Background:

  • Renal angiomyolipomas (AMLs) are mesenchymal tumors composed of smooth muscle, adipose tissue, and abnormal vasculature.
  • Lymphangiomatous-like foci are often observed in AMLs, but lymphatic differentiation has not been systematically studied.

Purpose of the Study:

  • To investigate the presence and distribution of lymphatic differentiation in renal angiomyolipomas.
  • To characterize the morphology and location of lymphatic vessels within different AML subtypes.

Main Methods:

  • Retrospective analysis of 12 renal angiomyolipomas from 10 patients.
  • Immunohistochemical staining for melanocytic markers (HMB-45, Melan-A) and lymphatic endothelial cell markers (podoplanin, D2-40).
  • Evaluation of the distribution and pattern of lymphatic differentiation across tumor variants.

Main Results:

  • All 12 AMLs expressed melanocytic markers.
  • Positive staining for podoplanin in all tumors and D2-40 in 6 tumors confirmed lymphatic differentiation.
  • Lymphatic differentiation was most prevalent in myoid areas of triphasic AMLs and leiomyoma-like variants.
  • Lymphatics appeared as isolated vessels in adipose tissue and clustered, sinusoidal patterns in myoid regions, often near abnormal arteries.

Conclusions:

  • Lymphatic differentiation is a common feature in renal angiomyolipomas.
  • The distribution of lymphatic vessels varies by AML subtype, with a preference for myoid areas.
  • These findings support the concept of mesenchymal pluripotentiality in renal angiomyolipomas.