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Drugs that Destabilize Microtubules

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Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...

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Related Experiment Video

Updated: Jun 28, 2026

An Automated Method to Perform The In Vitro Micronucleus Assay using Multispectral Imaging Flow Cytometry

An Automated Method to Perform The In Vitro Micronucleus Assay using Multispectral Imaging Flow Cytometry

Published on: May 13, 2019

Colchicine update: 2008.

Robert A Terkeltaub¹

¹VA Medical Center, San Diego, CA 92161, USA. rterkeltaub@ucsd.edu

Seminars in Arthritis and Rheumatism

|November 1, 2008

Summary

Recent advances refine oral colchicine therapy by identifying new targets and understanding drug interactions. This improves efficacy and safety for various inflammatory and nonrheumatic diseases.

Area of Science:

Pharmacology and Toxicology
Molecular Biology
Clinical Medicine

Background:

Colchicine, a long-established drug, has seen recent advancements in understanding its molecular mechanisms.
Its therapeutic applications extend beyond rheumatic diseases to cardiovascular, hepatic, and renal conditions.

Purpose of the Study:

To review recent advances in colchicine's molecular mechanisms of action and disposition.
To explore its cellular targets, disease applications, and guidelines for oral use.

Main Methods:

A comprehensive literature review of English and non-English publications from 1998 to July 2008.
Analysis of 1512 publications focusing on colchicine pharmacology, toxicology, and clinical applications.

Main Results:

Related Experiment Videos

Last Updated: Jun 28, 2026

An Automated Method to Perform The In Vitro Micronucleus Assay using Multispectral Imaging Flow Cytometry

An Automated Method to Perform The In Vitro Micronucleus Assay using Multispectral Imaging Flow Cytometry

Published on: May 13, 2019

Oral colchicine therapy is evolving with novel targets like NALP3 and pyrin.
Drug-drug interactions (e.g., with clarithromycin, cyclosporine) and toxicity predictors (ABCB1, CYP3A4) are better understood.
Colchicine shows promise in nonrheumatic diseases and has had its injectable form withdrawn from the market.

Conclusions:

Oral colchicine possesses unique anti-inflammatory and antiproliferative properties beneficial for various diseases.
Recent progress has enhanced the prediction of both colchicine's efficacy and potential toxicities.