Related Experiment Video
Updated: Jun 28, 2026

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products
Published on: December 5, 2020
Carbon analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities
Takuya Uchida1, Atsushi Somada, Yoshiko Kagoshima
1Medicinal Chemistry Research Laboratories II, Daiichi Sankyo Co., Ltd, 1-16-13, Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan.
Abstract:
A new series of triazole compounds possessing a carbon atom in place of a sulfur atom were efficiently synthesized and their in vitro antifungal activities were investigated. The carbon analogs showed excellent in vitro activity against Candida, Cryptococcus, and Aspergillus species. The MICs of compound 1c against C. albicans ATCC24433, C. neoformans TIMM1855, and A. fumigatus ATCC26430 were 0.016, 0.016, and 0.125 microg/mL, respectively (MICs of fluconazole: 0.5, >4, and >4 microg/mL; MICs of itraconazole: 0.125, 0.25, and 0.25 microg/mL).
Related Concept Videos
Antifungal Agents
Antiviral Nucleoside Inhibitors
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Antiprotozoal Agents

