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A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
13:56

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Published on: July 18, 2013

VirusMINT: a viral protein interaction database.

Andrew Chatr-aryamontri1, Arnaud Ceol, Daniele Peluso

  • 1Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.

Nucleic Acids Research
|November 1, 2008
PubMed
Summary
This summary is machine-generated.

The VirusMINT database catalogs over 5000 interactions between viral and human proteins, aiding the study of viral infection impacts on host physiology. This resource helps researchers understand how virus proteins disrupt cellular networks.

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Last Updated: Jun 28, 2026

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Published on: July 18, 2013

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
11:28

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Published on: October 7, 2011

Identification of Protein Interaction Partners in Mammalian Cells Using SILAC-immunoprecipitation Quantitative Proteomics
12:53

Identification of Protein Interaction Partners in Mammalian Cells Using SILAC-immunoprecipitation Quantitative Proteomics

Published on: July 6, 2014

Area of Science:

  • Virology
  • Molecular Biology
  • Bioinformatics

Background:

  • Viral infections significantly alter host physiology by disrupting cellular protein interactions.
  • Understanding these perturbations is crucial for comprehending viral pathogenesis.
  • The VirusMINT database consolidates known viral-human protein interactions from scientific literature.

Purpose of the Study:

  • To create and maintain a comprehensive database of viral and human protein interactions.
  • To facilitate research into the molecular mechanisms of viral infections.
  • To provide a searchable resource for exploring virus-host protein interaction networks.

Main Methods:

  • Systematic literature curation of published protein-protein interactions.
  • Focus on medically relevant viruses including papillomaviruses, HIV-1, EBV, HBV, HCV, herpesviruses, and SV40.
  • Data organization and storage in the VirusMINT database.

Main Results:

  • The VirusMINT database contains over 5000 interactions.
  • It includes data on more than 490 unique viral proteins from over 110 viral strains.
  • Interactions involve proteins from key human pathogens.

Conclusions:

  • VirusMINT serves as a valuable, accessible resource for researchers studying virus-host interactions.
  • The database aids in understanding the molecular basis of viral diseases.
  • It supports the development of targeted antiviral strategies through detailed interaction data.