Related Experiment Video
Updated: Jun 28, 2026
Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
Protective effect of geranylgeranylacetone on cisplatin ototoxicity
Hai Ying Yin1, Xiu Fang Ma, Fang Liu
1Department of Otorhinolaryngology, Qilu Hospital, Shandong University, Wen Hua Xi Road 107, Jinan, China.
Background:
Geranylgeranylacetone (GGA) has the ability to induce heat shock proteins and to protect cells from apoptotic insults. This study aims to investigate whether GGA has a protective effect on cisplatin (CDDP) ototoxicity.
Methods:
The auditory threshold was assessed using the auditory brainstem response test. Hsp70 and C-reactive protein expressions were investigated by Western blot analysis. The amount of hair cells was counted under scanning electron microscopy.
Results:
The auditory threshold and the percentage of missing outer hair cells in the CDDP group were significantly higher than in the GGA + CDDP group. C-reactive protein expression was less in the GGA + CDDP group compared with the CDDP group. Hsp70 expression showed an adverse result.
Conclusion:
It was suggested that GGA had a protective effect on CDDP ototoxicity.
