Protective effect of geranylgeranylacetone on cisplatin ototoxicity
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Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
Hai Ying Yin1, Xiu Fang Ma, Fang Liu
1Department of Otorhinolaryngology, Qilu Hospital, Shandong University, Wen Hua Xi Road 107, Jinan, China.
Background:
Geranylgeranylacetone (GGA) has the ability to induce heat shock proteins and to protect cells from apoptotic insults. This study aims to investigate whether GGA has a protective effect on cisplatin (CDDP) ototoxicity.
Methods:
The auditory threshold was assessed using the auditory brainstem response test. Hsp70 and C-reactive protein expressions were investigated by Western blot analysis. The amount of hair cells was counted under scanning electron microscopy.
Results:
The auditory threshold and the percentage of missing outer hair cells in the CDDP group were significantly higher than in the GGA + CDDP group. C-reactive protein expression was less in the GGA + CDDP group compared with the CDDP group. Hsp70 expression showed an adverse result.
Conclusion:
It was suggested that GGA had a protective effect on CDDP ototoxicity.
