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Micro-CT Imaging and Morphometric Analysis of Mouse Neonatal Brains

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The Neuroterrain 3D Mouse Brain Atlas.

Louise Bertrand¹, Jonathan Nissanov

¹Department of Neurobiology and Anatomy, Drexel University College of Medicine Philadelphia, PA, USA.

Frontiers in Neuroinformatics

|November 1, 2008

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Researchers developed a new anatomical atlas for the C57BL/6J mouse brain. This neuroinformatics tool aids in the automated analysis of histological images for neurogenetic research.

Area of Science:

Neuroinformatics
Neuroimaging
Computational Neuroscience

Background:

Neuroinformatics aims to create tools for accessing, searching, and analyzing anatomical imagery.
Image analysis tools include registration algorithms and anatomical models (atlases).

Purpose of the Study:

To construct an anatomical atlas model for the C57BL/6J mouse.
To support automated delineation of the Mouse Brain Library database.

Main Methods:

Development of computer vision tools for mesoscale image analysis.
Creation of an atlas containing bitmap images and anatomical boundary templates.

Main Results:

Construction of a novel anatomical atlas for the C57BL/6J mouse.

Keywords:

3D reconstruction atlas automated segmentation brain model neuroanatomy registration spatial normalization standard coordinate space

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The atlas serves as a model for automated image analysis.

Conclusions:

The developed mouse brain atlas is a valuable tool for neuroinformatics.
It facilitates automated delineation for neurogenetic research databases.