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Updated: Jan 15, 2026

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis

Published on: November 17, 2020

Primary central nervous system lymphoma.

Sharathkumar Bhagavathi¹, Jon D Wilson

¹Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48076, USA. vmsharathkumar@yahoo.com

Archives of Pathology & Laboratory Medicine

|November 4, 2008

Summary

This summary is machine-generated.

Primary central nervous system lymphoma (PCNSL) is a rare non-Hodgkin lymphoma affecting the brain. While its incidence is rising, PCNSL has a poorer prognosis than other lymphomas and requires combined treatment.

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Last Updated: Jan 15, 2026

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis

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Published on: November 17, 2020

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

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Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Area of Science:

Neurology
Oncology
Pathology

Background:

Primary central nervous system lymphoma (PCNSL) is an uncommon extranodal non-Hodgkin lymphoma with increasing incidence.
It affects both immunocompromised and immunocompetent individuals, often presenting with increased intracranial pressure and focal neurological deficits.

Purpose of the Study:

To summarize the key characteristics, diagnosis, and treatment of primary central nervous system lymphoma.
To highlight the challenges in understanding PCNSL pathogenesis and its differential diagnosis.

Main Methods:

Review of existing literature on PCNSL.
Analysis of clinical presentation, histopathology, and immunohistochemistry findings.
Discussion of treatment modalities and prognostic factors.

Main Results:

PCNSL most commonly presents as solitary, periventricular lesions and is typically a diffuse large B-cell lymphoma.
Characteristic angiocentric morphology and B-cell marker positivity aid diagnosis.
Differential diagnoses include gliomas, metastases, and infectious lesions.

Conclusions:

PCNSL is an aggressive brain lymphoma with a worse prognosis than systemic lymphomas.
Combined radiotherapy and chemotherapy are standard treatments.
Further research into molecular mechanisms and biomarkers is needed.