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Herpes simplex encephalitis after craniopharyngioma surgery.
Ji-Woong Kwon1, Byung-Kyu Cho, Eui Chong Kim
1Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Journal of Neurosurgery. Pediatrics
|November 4, 2008
Summary
A young girl developed herpes simplex encephalitis after craniopharyngioma surgery. Prompt diagnosis and antiviral treatment with acyclovir led to recovery, though some neurological deficits persisted.
Area of Science:
- Neurology
- Infectious Diseases
- Neurosurgery
Background:
- Craniopharyngioma surgery can carry risks of postoperative complications.
- Herpes simplex virus (HSV) can cause severe neurological infections.
Observation:
- A 13-year-old girl presented with rapid mental status decline 15 days post-craniopharyngioma surgery.
- Imaging revealed a progressing frontotemporal lobe lesion, elevated C-reactive protein, and HSV DNA in cerebrospinal fluid.
Findings:
- Herpes simplex encephalitis was diagnosed based on clinical and laboratory findings.
- High-dose intravenous acyclovir therapy was initiated.
Implications:
- Early diagnosis and aggressive antiviral treatment are crucial for improving outcomes in herpes simplex encephalitis.
- Prompt intervention can mitigate severe neurological damage and improve patient prognosis, even after complex surgeries.
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