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Updated: Jun 28, 2026

Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting
Published on: October 26, 2018
Cancer gene therapy with targeted adenoviruses
Houria Bachtarzi1, Mark Stevenson, Kerry Fisher
1University of Oxford, Department of Clinical Pharmacology, Old Road Campus Research Building, OX3 7DQ, Oxford, UK.
Background:
Clinical experience with adenovirus vectors has highlighted the need for improved delivery and targeting.
Objective:
This manuscript aims to provide an overview of the techniques currently under development for improving adenovirus delivery to malignant cells in vivo.
Methods:
Primary research articles reporting improvements in adenoviral gene delivery are described. Strategies include genetic modification of viral coat proteins, non-genetic modifications including polymer encapsulation approaches and pharmacological interventions.
Results/Conclusion:
Reprogramming adenovirus tropism in vitro has been convincingly demonstrated using a range of genetic and physical strategies. These studies have provided new insights into our understanding of virology and the field is progressing. However, there are still some limitations that need special consideration before adenovirus-targeted cancer gene therapy emerges as a routine treatment in the clinical setting.
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