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Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
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Final height in Swedish children with idiopathic growth hormone deficiency enrolled in KIGS treated optimally with

Otto Westphal1, Anders Lindberg,

  • 1Göteborg Pediatric Growth Research Center, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. otto.westphal@vgregion.se

Acta Paediatrica (Oslo, Norway : 1992)
|November 4, 2008
PubMed

Insights

Children with growth hormone deficiency (GHD) treated with human recombinant growth hormone (GH) achieved normal final height within their genetic potential. Some patients experienced disproportionality, but overall outcomes were positive.

Area of Science:

  • Pediatric endocrinology
  • Growth disorders
  • Hormone replacement therapy

Background:

  • Growth hormone deficiency (GHD) affects children's final height.
  • Human recombinant growth hormone (GH) is a standard treatment.
  • Understanding treatment outcomes is crucial for clinical practice.

Purpose of the Study:

  • To evaluate the final height achieved by children with GHD treated with GH.
  • To analyze height outcomes based on GHD severity and patient demographics.
  • To determine if GH therapy allows children to reach their genetic height potential.

Main Methods:

  • Retrospective analysis of 401 Swedish children with idiopathic GHD treated with GH.
  • Data collected from the KIGS database (1987-2006).
  • Analysis of height at entry, puberty onset, and near final height, grouped by sex, age, and GHD severity.

Main Results:

  • Mean final height, corrected for mid-parental height, was within the normal Swedish range for all groups.
  • Patients with severe GHD achieved final heights similar to the normal Swedish population.
  • Approximately 16% of patients exhibited disproportionality (short legs), correlating with parental short stature.

Conclusions:

  • GH replacement therapy enables children with idiopathic GHD to reach a final height within the normal range.
  • Treatment allows children to achieve their genetically determined height potential.
  • While most achieve normal height, a subset may show disproportionality, indicating the need for further investigation.
Abstract

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