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Related Experiment Video

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Production and Measurement of Organic Particulate Matter in a Flow Tube Reactor

Production and Measurement of Organic Particulate Matter in a Flow Tube Reactor

Published on: December 15, 2018

Testing limits to airflow perturbation device (APD) measurements.

Erika R Lopresti¹, Arthur T Johnson, Frank C Koh

¹Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA. erikalopresti@yahoo.com

Biomedical Engineering Online

|November 4, 2008

Summary

This summary is machine-generated.

The Airflow Perturbation Device (APD) accurately measures respiratory resistance, even with minor leaks or when adapted for ventilated patients using an oronasal mask and ventilator tube. Calibration is possible by adding resistance in series.

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Area of Science:

Respiratory Physiology
Medical Device Technology

Background:

The Airflow Perturbation Device (APD) measures respiratory resistance.
Accuracy limits for APD under conditions like leaks, oronasal mask use, and added resistance need investigation.
APD application in ventilated patients requires evaluation.

Purpose of the Study:

To assess the accuracy of APD measurements under various conditions.
To determine the impact of leaks, oronasal masks, and added resistance on APD readings.
To evaluate APD utility in ventilated patients.

Main Methods:

Ten healthy adult subjects (18-35 years) participated.
Experiments involved testing leaks (up to 6.4 mm tubes), an oronasal mask, added resistances, and a ventilator tube.
APD measurements were recorded under each condition.

Main Results:

Leaks up to two 3.2 mm tubes did not significantly alter APD measurements.
Larger leaks (4.8 and 6.4 mm) significantly reduced measured resistance.
Oronasal mask use for mouth or nose breathing showed no significant difference compared to a standard mouthpiece.
Added resistances increased APD measurements additively.
Ventilator tubing showed a non-significant reduction in measured resistance.

Conclusions:

APD measurements remain largely unaffected by leaks equivalent to two 3.2 mm tubes.
The APD can be adapted for ventilated, unconscious, or uncooperative patients using a ventilator tube and oronasal mask.
Added resistance can be used for qualitative calibration of the APD.