Related Experiment Video
Updated: Jun 28, 2026

Optimization of the Epimedii Folium Mutton-Oil Processing Technology and Testing Its Effect on Zebrafish Embryonic Development
Published on: March 17, 2023
Application of response surface methodology (RSM) for optimization of nutrient supplementation for Cr (VI) removal by
Shweta Sharma1, Anushree Malik, Santosh Satya
1Centre for Rural Development and Technology, Indian Institute of Technology Delhi, Hauz Khas, New Delhi , India.
Abstract:
Response surface methodology (RSM) involving central composite design (CCD) was employed to optimize the concentrations of different media components for growth and Cr (VI) removal (100 mg l(-1) initial concentration) by Aspergillus lentulus AML05 at pH 6.5. The interaction between five variables i.e. glucose, K(2)HPO(4), MgSO(4), yeast extract, NH(4)NO(3) was studied and modelled. The statistical analysis of the results showed that in the range studied, yeast extract had a significant effect on Cr (VI) removal and production of fungal biomass. The optimum combination predicted via RSM was confirmed through experiment, whereby almost complete removal (99.8%) of Cr (VI) was obtained within 120 h. The validation of these results in terms of field applicability was also tested by treating industrial effluent supplemented with key media components.
Related Concept Videos
Response Surface Methodology
The process of RSM involves several key steps:
Methods of Medium Optimization
Bioreactor Controls-III
