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Reconstructing the disease model and epigenetic networks for MLL-AF4 leukemia
Bernd B Zeisig1, Ngai Cheung, Jenny Yeung
1Leukaemogenesis Team, Section of Haemato-Oncology, The Institute of Cancer Research, Sutton, Greater London, UK.
Cancer Cell
|November 4, 2008
Abstract:
The lack of a proper animal model has impeded understanding of the molecular mechanism of leukemia associated with the MLL-AF4 fusion. In this issue of Cancer Cell, Krivtsov et al. report a much-improved murine Mll-AF4 model and propose a molecular link with H3K79 methylation mediated by the histone methyltransferase DOT1L.
