Spurious hyperbilirubinemia caused by naproxen
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Published on: November 30, 2022
Nafila Al Riyami1, Amanda C Zimmerman, Frances M Rosenberg
1University of British Columbia Department of Pathology and Laboratory Medicine, Vancouver, BC, Canada.
Objective:
To confirm that the naproxen metabolite O-desmethylnaproxen interferes with the Jendrassik and Grof method for total bilirubin and was a possible cause of spurious hyperbilirubinemia in a case of naproxen overdose.
Design And Methods:
Plasma was spiked with naproxen or O-desmethylnaproxen before total and direct bilirubin analysis.
Results:
O-desmethylnaproxen concentration showed a linear relationship with measured total bilirubin.
Conclusion:
O-demethylnaproxen interferes with the total bilirubin method. Interference of glucuronide metabolites of naproxen and O-demethylnaproxen is not excluded.
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