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Related Experiment Video

Updated: Jun 28, 2026

Zebrafish In Situ Spinal Cord Preparation for Electrophysiological Recordings from Spinal Sensory and Motor Neurons

Zebrafish In Situ Spinal Cord Preparation for Electrophysiological Recordings from Spinal Sensory and Motor Neurons

Published on: April 18, 2017

Notch-regulated perineurium development from zebrafish spinal cord.

Ho Kim¹, Suhyun Kim, Ah-Young Chung

¹Graduate School of Medicine, Korea University, Ansan, Gyeonggido 425-707, Republic of Korea.

Neuroscience Letters

|November 4, 2008

Summary

This study identifies fabp7a as a key gene in zebrafish spinal cord development. Notch signaling maintains fabp7a-expressing cells, revealing a new mechanism for perineurial development.

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Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development

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Published on: February 28, 2014

Area of Science:

Neuroscience
Developmental Biology
Cell Biology

Background:

The perineurium, a protective sheath in the developing central nervous system, is formed by perineurial cells with epithelial and myofibroblastoid properties.
The precise molecular mechanisms governing perineurial development are not fully understood.

Purpose of the Study:

To investigate the role of fabp7a, a brain lipid-binding protein, in perineurial development.
To elucidate the molecular pathways regulating perineurial glia formation in zebrafish.

Main Methods:

Utilized zebrafish embryos as a model system.
Examined the expression patterns of fabp7a.
Investigated the role of Notch signaling in perineurial development.

Main Results:

fabp7a is expressed in lateral floor plate cells and subsequently in perineurial glia within the zebrafish spinal cord.
Notch signaling was found to regulate perineurial glia development.
Notch signaling maintains fabp7a-expressing cells, crucial for perineurial development.

Conclusions:

fabp7a plays a significant role in the development of perineurial glia.
Notch signaling provides a novel regulatory mechanism for perineurial development by maintaining fabp7a expression.