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Updated: Jun 28, 2026

Live Imaging of Antifungal Activity by Human Primary Neutrophils and Monocytes in Response to A. fumigatus
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Published on: April 19, 2017

Complement induction and complement evasion in patients with cerebral aspergillosis.

Günter Rambach1, Hans Maier, Gianluca Vago

  • 1Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Fritz-Pregl-Str. 3, 6020 Innsbruck, Austria.

Microbes and Infection
|November 4, 2008
PubMed
Summary

Cerebral aspergillosis triggers increased complement synthesis in brain cells and macrophages, but the fungus employs evasion tactics like limiting C3 deposition and forming abscesses to survive complement attack.

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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
09:52

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Published on: March 9, 2018

Area of Science:

  • Neuroscience
  • Immunology
  • Mycology

Background:

  • Cerebral aspergillosis is a severe central nervous system infection.
  • Low cerebral complement levels contribute to insufficient immune responses.
  • Understanding fungal evasion is crucial for developing treatments.

Purpose of the Study:

  • Investigate cerebral complement expression following Aspergillus invasion.
  • Identify fungal mechanisms for evading complement-mediated immunity.
  • Correlate complement synthesis with immune cell activity in the brain.

Main Methods:

  • Immunohistochemical analysis of brain tissue from infected and non-infected individuals.
  • Statistical correlation analysis of complement expression levels.
  • Examination of fungal structures and complement deposition in situ.

Main Results:

  • Increased complement synthesis observed in astrocytes, neurons, oligodendrocytes, and macrophages.
  • Microglia showed limited participation in complement protein synthesis.
  • Aspergillus spp. utilize mechanisms like limiting C3 deposition and abscess formation to evade complement.

Conclusions:

  • Complement activation is a key factor in cerebral aspergillosis.
  • Fungal pathogens develop sophisticated evasion strategies against complement.
  • Targeting fungal evasion mechanisms presents potential therapeutic avenues.