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Related Experiment Video

Updated: Jun 28, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Keratoconus diagnosis with optical coherence tomography pachymetry mapping.

Yan Li1, David M Meisler, Maolong Tang

  • 1Center for Ophthalmic Optics and Lasers, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California 99033, USA.

Ophthalmology
|November 4, 2008
PubMed
Summary

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High-speed optical coherence tomography (OCT) pachymetry maps accurately detect abnormal corneal thinning in keratoconus. This OCT method shows high sensitivity and specificity, comparable to topographic indices for keratoconus diagnosis.

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Corneal Diseases

Background:

  • Keratoconus is characterized by progressive corneal thinning.
  • Accurate detection of corneal thinning is crucial for keratoconus diagnosis and management.
  • Traditional methods like Placido-ring topography have limitations in quantifying subtle corneal changes.

Observation:

  • A cross-sectional observational study involved 37 keratoconic eyes and 36 normal eyes.
  • High-speed anterior segment optical coherence tomography (OCT) was used to generate corneal pachymetry maps.
  • Key pachymetric parameters including minimum thickness, inferior-superior asymmetry, and thinning location were analyzed.

Findings:

  • Keratoconic corneas exhibited significantly thinner pachymetry compared to normal corneas.

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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
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Published on: July 24, 2020

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Last Updated: Jun 28, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

  • OCT pachymetry maps revealed focal thinning and increased asymmetry in keratoconic eyes.
  • The OCT pachymetry method achieved an area under the receiver operating characteristic curve (AROC) of 0.99 for keratoconus detection, outperforming the topographic KISA% index (AROC=0.91).

    • Implications:

    • High-speed OCT pachymetry is a highly accurate tool for detecting abnormal corneal thinning in keratoconus.
    • This OCT-based method offers comparable or superior diagnostic performance to existing topographic indices.
    • OCT pachymetry provides a valuable, sensitive, and specific approach for early and reliable keratoconus diagnosis.