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Pyrosequencing for Microbial Identification and Characterization
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Published on: August 22, 2013

What is 'Pierre Robin sequence'?

C C Breugem1, A B Mink van der Molen

  • 1Division of Pediatric Plastic Surgery, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3508 AB, Utrecht, The Netherlands. c.c.breugem@umcutrecht.nl

Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS
|November 4, 2008
PubMed
Summary
This summary is machine-generated.

Widespread confusion exists in defining Robin sequence, leading to inconsistent patient care and outcome studies. A unified definition, starting with micrognathia, glossoptosis, and airway compromise, is crucial for effective multidisciplinary treatment.

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Area of Science:

  • Medical Science
  • Pediatric Medicine
  • Genetics

Background:

  • Robin sequence lacks a universally accepted definition, complicating diagnosis and treatment.
  • Inconsistent nosology hinders understanding and comparison of patient outcomes.
  • Current definitions vary significantly among healthcare professionals.

Purpose of the Study:

  • To investigate the current understanding and definition of Robin sequence.
  • To identify the extent of definitional variability in clinical practice.
  • To propose a standardized definition for Robin sequence.

Main Methods:

  • A questionnaire was distributed at the Annual Dutch Cleft Palate Meeting.
  • Participants were asked to summarize characteristics for defining Robin sequence.
  • Responses from 66 attendees were analyzed to identify variations in definitions.

Main Results:

  • A total of 29 different descriptions for Robin sequence were identified.
  • The study revealed widespread confusion and lack of uniformity in defining the condition in the Netherlands.
  • This inconsistency impedes the comparison of outcome studies.

Conclusions:

  • A unified definition of Robin sequence is essential for effective multidisciplinary care.
  • The original description by Pierre Robin (micrognathia, glossoptosis, airway compromise) is proposed as a core definition.
  • Associated conditions like cleft palate or feeding problems can be added adjunctively.