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Influence of the pattern of hypertrophy on left ventricular twist in hypertrophic cardiomyopathy

B M van Dalen1, F Kauer, O I I Soliman

  • 1Department of Cardiology, The Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands. b.m.vandalen@erasmusmc.nl

Heart (British Cardiac Society)
|November 4, 2008
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) patients exhibit altered left ventricular (LV) twist, with specific patterns influenced by LV hypertrophy. Speckle tracking echocardiography (STE) reveals novel non-invasive indices for assessing LV function in HCM.

Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiac Mechanics

Background:

  • Left ventricular (LV) twist is crucial for LV function.
  • The impact of LV hypertrophy patterns on LV twist in hypertrophic cardiomyopathy (HCM) is not well understood.

Purpose of the Study:

  • To evaluate LV twist in a large cohort of HCM patients.
  • To correlate LV twist with different patterns of LV hypertrophy.

Main Methods:

  • Used speckle tracking echocardiography (STE) to assess LV mechanics.
  • Analyzed LV peak systolic rotation (Rot(max)) and twist (Twist(max)) in 43 HCM patients and 43 controls.
  • Measured LV untwisting during early diastole.

Main Results:

  • HCM patients showed increased basal rotation and overall twist compared to controls.
  • LV untwisting was reduced in HCM patients.
  • Significant differences in apical rotation and twist were observed between HCM patients with sigmoidal and reverse septal curvature.

Conclusions:

  • STE offers new non-invasive methods to assess LV function in HCM.
  • LV twist parameters (apical rotation and twist) are dependent on the specific pattern of LV hypertrophy in HCM.
Abstract

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