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[Changes in the liver circulation and kidney function during pulsatile and non-pulsatile perfusion].
Anesteziologiia I Reanimatologiia
|May 1, 1991
Summary
Pulsatile flow perfusion (PFP) leads to less fluid overload and better liver function compared to nonpulsatile flow perfusion (NPFP). PFP avoids negative impacts on hydration and bilirubin levels seen with NPFP.
Area of Science:
- Cardiovascular physiology
- Renal function
- Hepatobiliary system
Context:
- Cardiopulmonary bypass procedures often involve nonpulsatile flow perfusion (NPFP), which can lead to fluid imbalances and altered organ function.
- Pulsatile flow perfusion (PFP) is an alternative technique that may mitigate some of the adverse effects associated with NPFP.
Purpose:
- To compare the effects of pulsatile flow perfusion (PFP) versus nonpulsatile flow perfusion (NPFP) on fluid balance, renal function, and bilirubin levels during perfusion.
Summary:
- Pulsatile flow perfusion (PFP) requires a smaller infusion volume and results in less extravascular hyperhydration compared to nonpulsatile flow perfusion (NPFP).
- NPFP is associated with increased free water clearance, lower urinary osmolality, and a higher diuresis rate, whereas PFP maintains baseline values.
- While neither method significantly affected urinary sodium excretion or total hepatic flow, NPFP led to a significant increase in bilirubinemia, unlike PFP.
Impact:
- Pulsatile flow perfusion (PFP) offers a potential advantage in maintaining fluid balance and preserving liver function during perfusion procedures.
- These findings suggest PFP may be a superior alternative to NPFP for minimizing complications related to fluid overload and hyperbilirubinemia.