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Related Experiment Video

Updated: Jun 28, 2026

New Features in Visual Dynamics 3.0

New Features in Visual Dynamics 3.0

Published on: August 9, 2024

SMART 6: recent updates and new developments.

Ivica Letunic¹, Tobias Doerks, Peer Bork

¹EMBL, Meyerhofstrasse 1, 69012 Heidelberg, Germany.

Nucleic Acids Research

|November 4, 2008

Summary

This summary is machine-generated.

The Simple Modular Architecture Research Tool (SMART) enhances protein domain identification and annotation. Its latest version offers expanded genomic data, pathway integration, and improved interaction network visualization for researchers.

Related Experiment Videos

Last Updated: Jun 28, 2026

New Features in Visual Dynamics 3.0

New Features in Visual Dynamics 3.0

Published on: August 9, 2024

Area of Science:

Bioinformatics
Computational Biology
Molecular Biology

Background:

Protein domain identification and annotation are crucial for understanding protein function and evolution.
Existing tools may lack comprehensive domain models or user-friendly interfaces for comparative analysis.
The Simple Modular Architecture Research Tool (SMART) provides a curated database for protein domain analysis.

Purpose of the Study:

To present the recent developments and enhancements in the SMART online tool.
To improve data integration, user-friendliness, and analytical capabilities for protein domain research.
To expand the scope of SMART to include pathway information and advanced network visualization.

Main Methods:

Curated protein domain models were maintained and updated.
The underlying protein database was expanded using data from completely sequenced genomes.
Domain annotations were integrated with metabolic pathway data and links to pathway resources.
The interaction network view was redesigned and expanded.

Main Results:

The SMART database now includes manually curated models for 784 protein domains.
The protein database was expanded to cover 630 species.
Domain annotations were enriched with metabolic pathway information.
The redesigned interaction network view supports over 2 million proteins.
SMART now supports queries via Distributed Annotation System (DAS) and Simple Object Access Protocol (SOAP) web services.

Conclusions:

The updated SMART tool offers a more comprehensive and user-friendly platform for protein domain research.
Enhanced data integration and new features facilitate deeper insights into protein architecture and function.
SMART's expanded capabilities support a wider range of biological inquiries, from domain analysis to pathway and interaction studies.