Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Automated Microbial Diagnostics

Automated Microbial Diagnostics

Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...

Enzyme-Linked Immunosorbent Assay

Enzyme-Linked Immunosorbent Assay

In 1971, Peter Perlman and Eva Engvall developed an Enzyme-linked immunosorbent assay (ELISA or EIA). ELISA differs from western blot in that the assays are conducted in microtiter plates or in vivo rather than on an absorbent membrane.
There are many different types of ELISAs, but they all involve an antibody molecule whose constant region binds an enzyme, leaving the variable region free to bind its specific antigen. Enzyme-substrate reaction allows the antigen to be visualized or quantified.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Editorial Expression of Concern: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.

Nature immunology·2026

Same author

IMGT Nomenclature and IMGT Unique Numbering: The Two Pillars of 35 Years of Immunoinformatics for Immunoglobulins (IG) or Antibodies and T Cell Receptors (TR).

Methods in molecular biology (Clifton, N.J.)·2026

Same author

IMGT<sup>®</sup> Nomenclature of Immunoglobulins (IG) or Antibodies and T Cell Receptors (TR): A Common Language for Immunoinformatics and Artificial Intelligence (AI).

Antibodies (Basel, Switzerland)·2026

Same author

Unraveling IGK locus in dog breeds: IMGT<sup>®</sup> new insights into canine immunogenetics.

NAR genomics and bioinformatics·2026

Same author

Therapeutic monoclonal antibodies repurposing in oncology via IMGT/mAb-KG embeddings.

BMC medical informatics and decision making·2026

Same author

Blended Phenotypes in Siblings: Dual Diagnoses of Nicolaides-Baraitser and Craniosynostosis Syndromes.

Molecular syndromology·2025

Search research articles

Related Experiment Video

Updated: Jun 28, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

IMGT, the international ImMunoGeneTics information system.

Marie-Paule Lefranc¹, Véronique Giudicelli, Chantal Ginestoux

¹IMGT, the international ImMunoGeneTics information system, Université Montpellier 2, Laboratoire d'ImmunoGénétique Moléculaire LIGM, UPR CNRS 1142, Institut de Génétique Humaine IGH, 34396 Montpellier Cedex 5, France. marie-paule.lefranc@igh.cnrs.fr

Nucleic Acids Research

|November 4, 2008

Summary

IMGT provides standardized immunogenetics data for researchers worldwide. This comprehensive system supports diverse fields including medical research, biotechnology, and diagnostics.

More Related Videos

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

Related Experiment Videos

Last Updated: Jun 28, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

Area of Science:

Immunogenetics
Immunoinformatics
Biotechnology

Background:

The International ImMunoGeneTics information system (IMGT) was established to manage complex immunogenetics data.
IMGT has become a global reference due to its unique ontology, IMGT-ONTOLOGY.
It serves as a high-quality, integrated knowledge resource for immunogenetics.

Purpose of the Study:

To provide a standardized and comprehensive resource for immunogenetics data.
To facilitate access to integrated data on immunoglobulins, T cell receptors, and related proteins.
To support research and applications in various fields of immunology and biotechnology.

Main Methods:

Development of a unique ontology (IMGT-ONTOLOGY) for standardization.
Integration of data from genome, proteome, genetics, and 3D structures.
Creation of specialized databases (e.g., IMGT/LIGM-DB) and interactive online tools.

Main Results:

IMGT offers standardized access to diverse immunogenetic data for human and vertebrate species.
The system includes multiple databases, analysis tools, and extensive knowledge pages.
It covers immunoglobulins, T cell receptors, MHC, IgSF, MhcSF, and related immune proteins.

Conclusions:

IMGT is an essential resource for medical research, veterinary science, and biotechnology.
Its applications span autoimmune diseases, infectious diseases, antibody engineering, and diagnostics.
The freely accessible IMGT system advances immunogenetics and immunoinformatics globally.