Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Nondisjunction01:29

Nondisjunction

During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

System-Level Analysis of Japan's Pediatric-Perinatal Disaster Liaison Operations During the 2024 Noto Earthquake.

Pediatrics international : official journal of the Japan Pediatric Society·2026
Same author

Postoperative Nausea and Vomiting After Deep Sedation for Radiofrequency Catheter Ablation in Pediatric Patients.

Journal of arrhythmia·2026
Same author

Thalidomide for CGD-related inflammatory bowel disease: A randomized, double-blind trial.

Journal of human immunity·2026
Same author

CD40.HIVEnv, an antibody mediated vaccine, induces long-term and recall immunogenicity in non-HIV-1 infected volunteers.

Scientific reports·2026
Same author

Associations of weight loss, low serum albumin, and their combination with mortality risk in older adults receiving home medical care.

BMC research notes·2026
Same author

Systematic review of hematopoietic stem cell transplantation in patients with ataxia telangiectasia: a case report and an individual patient-level analysis.

Frontiers in immunology·2026

Related Experiment Video

Updated: Jun 28, 2026

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
09:35

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Published on: April 20, 2021

Somatic mosaicism in primary immune deficiencies.

Taizo Wada1, Fabio Candotti

  • 1Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.

Current Opinion in Allergy and Clinical Immunology
|November 4, 2008
PubMed
Summary

Somatic mosaicism, where revertant cells arise, is common in primary immunodeficiency diseases. These cells can alter clinical outcomes and immune function, offering insights into cell and gene therapy.

More Related Videos

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes
08:12

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes

Published on: November 1, 2011

Related Experiment Videos

Last Updated: Jun 28, 2026

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
09:35

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Published on: April 20, 2021

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes
08:12

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes

Published on: November 1, 2011

Area of Science:

  • Immunology
  • Genetics
  • Molecular Biology

Background:

  • Spontaneous genetic reversions and second-site mutations leading to revertant somatic mosaicism are not well understood.
  • These phenomena appear to occur frequently in primary immunodeficiency diseases.

Purpose of the Study:

  • To summarize reported cases of revertant somatic mosaicism in primary immunodeficiency diseases.
  • To focus on recent observations and their implications.

Main Methods:

  • Review of reported clinical cases.
  • Molecular analysis of revertant cells.

Main Results:

  • Revertant cells can lead to attenuated clinical phenotypes in some patients with primary immunodeficiency diseases.
  • Emerging evidence suggests revertant cells may also cause immune dysregulation.
  • A wide range of genetic alterations can cause revertant somatic mosaicism.

Conclusions:

  • Revertant somatic mosaicism is likely more common in primary immunodeficiency diseases than previously thought.
  • Studying this phenomenon provides insights into disease mechanisms.
  • Findings may indirectly inform the development of cell and gene therapies for these conditions.