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Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice

Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice

Published on: March 15, 2024

Predicting female depression across puberty: a two-nation longitudinal study.

George C Patton¹, Craig Olsson, Lyndal Bond

¹Centre for Adolescent Health, Murdoch Childrens Research Institute, Parkville, Australia. george.patton@rch.org.au

Journal of the American Academy of Child and Adolescent Psychiatry

|November 4, 2008

Summary

Pubertal development increases the risk of new and ongoing depressive symptoms in girls. Poor emotional control is a key predictor, highlighting potential targets for early intervention in adolescent females.

Related Experiment Videos

Last Updated: Jun 28, 2026

Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice

Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice

Published on: March 15, 2024

Area of Science:

Developmental Psychology
Adolescent Health
Mental Health Research

Background:

Puberty is a critical developmental period marked by significant biological and psychosocial changes.
Understanding factors influencing mental health during adolescence is crucial for early intervention.

Purpose of the Study:

To prospectively investigate the relationship between pubertal stage and the emergence and continuation of depressive symptoms.
To identify risk factors associated with depressive symptoms during puberty in adolescents.

Main Methods:

A three-wave longitudinal study involving 5,769 students aged 10-15 years in the US and Australia.
Assessed depressive symptoms using the Short Mood and Feelings Questionnaire.
Measured pubertal status via the self-report Pubertal Development Scale.

Main Results:

Advancing pubertal stage was associated with increased risk of depressive symptoms in females across all study waves.
Higher risk for both new cases (incident) and persistent depressive symptoms was observed in females during puberty.
Poor emotional control predicted incident depressive symptoms, largely explaining the pubertal rise in females. Family conflict and bullying predicted symptom persistence.

Conclusions:

Pubertal progression is a risk factor for the onset and persistence of depressive symptoms in females.
Social adversities like family conflict and bullying contribute to symptom persistence but not the pubertal rise in depression.
Identifying poor emotional control in girls may serve as an early marker for depression risk and a target for preventive strategies.