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Extrapulmonary small cell carcinoma localized in lymph nodes: is it a different clinical entity?
Irfan Cicin1, Ufuk Usta, Hakan Karagol
1Department of Medical Oncology, Faculty of Medicine, Trakya University, Edirne, Turkey. irfancicin@hotmail.com
Acta Oncologica (Stockholm, Sweden)
|November 4, 2008
Summary
Small cell carcinoma (SmCC) exclusively in lymph nodes shows excellent outcomes and survival rates. This suggests lymph node SmCC may be a distinct clinical entity, differing from pulmonary and other extrapulmonary forms.
Area of Science:
- Oncology
- Pathology
- Medical Research
Background:
- Extrapulmonary small cell carcinomas (EPSCC) present varied clinical progressions based on primary site.
- This review focuses on small cell carcinoma (SmCC) solely in lymph nodes, with no detectable primary tumor elsewhere.
Purpose of the Study:
- To analyze the clinical behavior, treatment response, and prognosis of SmCC exclusively localized in lymph nodes.
- To determine if lymph node-localized SmCC represents a distinct clinical entity.
Main Methods:
- A systematic literature search of PubMed (1980-2007) identified 11 English-language publications.
- Data from 28 individual patients with lymph node SmCC were scrutinized for epidemiological, clinical, pathological, and prognostic factors.
Main Results:
- Patient characteristics (age, gender, smoking) mirrored other EPSCCs.
- Median survival was not reached (42+ months), with a 3-year survival rate of 79%.
- Seventy-seven percent had limited-stage disease, responding well to various treatments, with 71% recurrence-free at limited stage.
Conclusions:
- SmCC localized in lymph nodes demonstrated superior clinical behavior and survival compared to pulmonary and other non-pulmonary SmCCs.
- The findings suggest that lymph node-localized SmCC could be a separate clinical entity.
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