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Updated: Jun 28, 2026

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Creation of a Rodent Model of Abdominal Aortic Aneurysm by Blocking Adventitial Vasa Vasorum Perfusion
Published on: November 8, 2017
Vascular wall flow-induced forces in a progressively enlarged aneurysm model.
Panagiotis Neofytou1, Sokrates Tsangaris, Michalis Kyriakidis
1Thermal-Hydraulics and Multiphase Flow Laboratory, INT-RP, NCSR Demokritos, Athens, Greece. panosn@ipta.demokritos.gr
Computer Methods in Biomechanics and Biomedical Engineering
|November 4, 2008
Summary
This study numerically investigates blood flow in abdominal aortic aneurysm models. It reveals how aneurysm growth and non-Newtonian blood flow impact wall forces, crucial for understanding aneurysm progression.
Area of Science:
- Biomedical Engineering
- Fluid Dynamics
- Computational Science
Background:
- Abdominal aortic aneurysms (AAAs) pose significant health risks.
- Understanding blood flow dynamics within AAAs is critical for predicting rupture risk.
- Existing models often simplify blood rheology, potentially affecting accuracy.
Purpose of the Study:
- To numerically investigate unsteady blood flow in an abdominal aortic aneurysm model.
- To analyze the distribution of flow-induced forces on the aneurysm wall.
- To examine the impact of aneurysm growth and non-Newtonian blood properties on these forces.
Main Methods:
- Utilized a computational fluid dynamics (CFD) code based on the finite volume method.
- Employed the Quemada non-Newtonian model to simulate blood's two-phase rheological behavior.
- Compared results with a Newtonian flow model and analyzed three degrees of aneurysm growth.
Main Results:
- Characterized the flow field and distribution of flow-induced forces within the AAA model.
- Demonstrated variations in pressure and wall shear stress distributions with increasing aneurysm size.
- Highlighted differences between Newtonian and non-Newtonian blood flow simulations.
Conclusions:
- Aneurysm growth significantly alters flow patterns and wall stress distributions.
- Non-Newtonian blood properties influence the hemodynamics within AAAs.
- Findings provide insights into the biomechanics of AAA progression and potential rupture.

