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Updated: Jun 28, 2026

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
Published on: August 17, 2022
Age-dependent changes in oxygen tension, radiation dose and sensitivity within normal and diseased coronary
1Radiation Biology and Health Physics Branch, Atomic Energy of Canada Limited (AECL), Ontario, Canada. richardr@aecl.ca
Purpose:
The aim is to assess the change with age and disease of the oxygen concentration within the coronary artery walls.
Materials And Methods:
In an accompanying paper, Part A, the age-dependent morphology and composition for the wall layers of normal and diseased coronary arteries were developed from published data. In this paper, Part B, the oxygen concentration in the coronary artery walls was evaluated taking account the diffusion of oxygen from blood and the solubility of oxygen in tissues. Part C evaluates the oxygen effect and its biological implications for different radiations.
Results:
Diseased arteries exhibited a relatively moderate increase in the solubility of oxygen (
Conclusion:
Based on simulation results from the one-dimensional diffusion model, extensive hypoxic areas were determined for atherosclerotic arteries in this analysis of oxygen levels in coronary arteries modelling for the first time the effects of age and disease and associated changes in oxygen solubility due to the presence of lipids and calcium.
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