Related Experiment Video
Updated: Jun 28, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
Published on: January 26, 2024
The relationship between serum concentration of free testosterone and pre-eclampsia
Valentina Ghorashi1, Mehrdad Sheikhvatan
1Shahid Beheshti University of Medical Sciences, Tehran, Iran. valentina_ghorashi@yahoo.com
Introduction:
Hyperandrogenism may be implicated in the pathogenesis of pre-eclampsia. We hypothesised that there may be a difference between the levels of testosterone in pregnant women complicated with pre-eclampsia and those of matched women without this complication.
Material And Methods:
A case-control study conducted in Tehran, Iran between January and June 2006 included 20 women with moderate to severe pre-eclampsia and 20 normotensive pregnant women without complications who were matched for age, body mass index and gravity. Maternal levels of free testosterone was measured in the two groups and compared.
Results:
Free testosterone levels were significantly higher in the pre-eclamptic group (mean = 1.97, SD = 0.58, median = 1.90 ng/dL) than in the control group (mean = 0.58, SD = 0.29, median=0.50 ng/dL) (P < 0.001).
Conclusions:
An increase in serum free testosterone concentration may be considered an important risk factor for pre-eclampsia and might be implicated in the pathogenesis of pre-eclampsia.
Related Concept Videos
Testosterone: Functions and Regulation
Hypertension III: Clinical Manifestations and Diagnostic Studies
Gonadal and Placental Hormones
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...
Teratogenicity
Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum Studies: Renal Function Tests
