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Updated: Jun 28, 2026

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
Published on: April 16, 2015
Functionally distinct NK-cell subsets: developmental origins and biological implications
1Immunology Department, Institut Pasteur, Paris, France. disanto@pasteur.fr
Abstract:
NK cells were initially identified based on their capacity to destroy susceptible target cells via granule-mediated cytotoxicity. Subsequently, NK-cell cytokine production (IFN-gamma, TNF-alpha) was shown to be critical in restricting pathogen infection, defining a non-cytotoxic role for NK cells in host defense. Recently, specialized NK-cell subsets with biased effector functions have been described in mice and man. This overview will consider the developmental origins and biological implications of this NK-cell diversification.
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