Is overcoming hormone resistance in breast cancer possible?
G Orphanos1, N Kakoullou, A Ardavanis
1Department of Oncology, Nicosia General Hospital, Nicosia, Cyprus. georgeorphanosvp@hotmail.com
Abstract:
The administration of hormones plays a major role in the treatment of hormone receptor-expressing breast cancers (BCs), both in the adjuvant setting as well as in advanced disease. Hormone-responsive tumors almost uniformly develop resistance, either independently or as a result of exposure to hormones. Overcoming this phenomenon constitutes a perpetual challenge to researchers and clinical oncologists. Understanding the mechanisms leading to hormone resistance is crucial to its inhibition or, at least, its delayed onset. This manuscript provides a brief review of this topic.
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