From microcirculation to cardiac event: protection with Preterax
1Medical Research Council Clinical Sciences Centre and National Heart and Lung institute, Imperial College, London, UK. paolo.camici@csc.mrc.ac.uk
Summary
Antihypertensive medications perindopril and indapamide may reverse coronary microvascular dysfunction in patients with arterial hypertension and left ventricular hypertrophy. This treatment may help prevent ischemic heart disease.
Area of Science:
- Cardiovascular Medicine
- Clinical Pharmacology
Background:
- Coronary microvascular dysfunction is implicated in cardiovascular morbidity and mortality in conditions like arterial hypertension.
- This dysfunction stems from vascular remodeling and abnormal hemodynamics.
- The potential for antihypertensive treatments to reverse coronary microvascular changes is not well-established.
Purpose of the Study:
- To investigate whether antihypertensive treatment can reverse coronary microvascular dysfunction.
- To assess the impact of perindopril and indapamide on coronary microvasculature in patients with arterial hypertension and left ventricular hypertrophy.
Main Methods:
- A study involving patients with arterial hypertension and left ventricular hypertrophy.
- Treatment with a combination of perindopril and indapamide for six months.
- Non-invasive myocardial blood flow measurement using positron emission tomography at rest and during hyperemia.
Main Results:
- Six months of treatment led to a significant reduction in blood pressure and left ventricular mass.
- A significant increase in resting and hyperemic myocardial blood flow was observed.
- Preliminary findings suggest a reversal of coronary microvascular dysfunction.
Conclusions:
- Treatment with perindopril and indapamide may reverse coronary microvascular dysfunction in hypertensive patients with left ventricular hypertrophy.
- This reversal might contribute to the prevention of ischemic heart disease.
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