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Updated: Jun 28, 2026

Guidelines for Elective Pediatric Fiberoptic Intubation

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

New ADVANCEs in guidelines.

Luis M Ruilope¹

¹Unidad de Hipertensión, Hospital 12 de Octubre, Avenida de Cordoba s/n, 28041 Madrid, Spain. ruilope@ad-hocbox.com

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension

|November 5, 2008

Summary

The ADVANCE study found that combining perindopril and indapamide in diabetic patients with hypertension significantly lowers blood pressure and protects against cardiovascular and renal damage, reducing all-cause mortality.

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Last Updated: Jun 28, 2026

Guidelines for Elective Pediatric Fiberoptic Intubation

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

Area of Science:

Cardiology
Nephrology
Endocrinology

Background:

Recent hypertension guidelines highlight elevated cardiovascular and renal risks in diabetic patients.
Prediabetes and metabolic syndrome are recognized as significant risk factors.

Purpose of the Study:

To evaluate the impact of a fixed perindopril and indapamide combination on cardiovascular and renal outcomes in diabetic patients.
To assess the efficacy of this combination in managing hypertension and associated risks in diabetes.

Main Methods:

Utilized a fixed-dose combination of perindopril and indapamide in diabetic patients with varying blood pressure levels.
Integrated this therapy with existing antihypertensive, metabolic, and lipid management strategies.
Focused on renin-angiotensin system suppression for comprehensive cardiorenal protection.

Main Results:

The combination therapy significantly reduced blood pressure in patients with diabetes.
Demonstrated substantial protection of cardiovascular and renal systems against diabetes-related damage.
Observed a significant decrease in all-cause mortality as a key finding.

Conclusions:

The fixed combination of perindopril and indapamide effectively lowers blood pressure and suppresses the renin-angiotensin system.
This therapeutic approach improves cardiovascular and renal prognosis in diabetic patients with hypertension.
The ADVANCE study provides strong evidence for the benefits of this combination in managing high-risk diabetic populations.