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Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
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Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

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Related Experiment Video

Updated: Jun 28, 2026

Autoradiographic Measurements of [14C]-Iodoantipyrine in Rat Brain Following Central Post-Stroke Pain
07:27

Autoradiographic Measurements of [14C]-Iodoantipyrine in Rat Brain Following Central Post-Stroke Pain

Published on: July 18, 2016

[Central poststroke pain].

Ranka Baraba Vurdelja1, Hrvoje Budincević, Miljenka Planjar Prvan

  • 1Opća bolnica "Sveti Duh", Zavod za neurologiju, 10000 Zagreb.

Lijecnicki Vjesnik
|November 5, 2008
PubMed
Summary

Central poststroke pain, a neuropathic condition following stroke, requires attention. First-line treatments include specific antidepressants and antiepileptic drugs.

Area of Science:

  • Neurology
  • Pain Medicine
  • Neuroscience

Context:

  • Central poststroke pain (CPSP) is a debilitating neuropathic pain condition.
  • It arises from damage to the central nervous system following a stroke.
  • CPSP is localized to the area affected by the cerebrovascular lesion.

Purpose:

  • To highlight the clinical significance of central poststroke pain.
  • To summarize key clinical features and proposed pathophysiological mechanisms.
  • To inform rational therapeutic strategies for CPSP management.

Summary:

  • Therapeutic guidelines for CPSP rely on clinical experience and expert opinion due to limited randomized controlled trials.
  • First-line pharmacological treatments include tricyclic antidepressants (e.g., amitriptyline, nortriptyline) and antiepileptic drugs (e.g., lamotrigine, gabapentin, pregabalin, carbamazepine).

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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

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Published on: January 21, 2020

  • Second-line options encompass tramadol, opioids, and fluvoxamine.

    • Impact:

    • Provides a concise overview of central poststroke pain for clinicians and researchers.
    • Emphasizes evidence-based and expert-guided treatment approaches.
    • Contributes to better understanding and management of post-stroke neuropathic pain.