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[The association of tyrosine hydroxylase gene polymorphism with mental disorder]
Jian Yu1, Hao Pang, Bao-Jie Wang
1School of Forensic Medicine, China Medical University, Shenyang 110001, China. yujian0905@sina.com
Objective:
To evaluate the relationship between the tyrosine hydroxylase (TH) gene and mental disorder by comparing the two TH gene SNP points (extron 3 and intron 9) of patients with mental disorders and normal human.
Methods:
DNA extracted from specimens of patients and normal subjects were quantified by using Real-time PCR.
Results:
(1) G334A distribution was: G=0.133, A=0.867 in patients with schizophrenia, G=0.116, A=0.884 in patients with depression, and G=0.214, A=0.786 in normal group. (2) C5162G distribution was: C=0.962, G=0.038 in patients with schizophrenia, C=0.959, G=0.041 in patients with depression, and C=0.961, G=0.039 in normal group.
Conclusion:
There are statistically significant differences in G334A locus between normal people and patients with mental disorders, but no statistically significant differences in C5162G locus.
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