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Updated: Jun 28, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
C2-symmetric bis-hydrazones as ligands in the asymmetric Suzuki-Miyaura cross-coupling
Antonio Bermejo1, Abel Ros, Rosario Fernández
1Departamento de Química Orgánica, Universidad de Sevilla, Apartado de Correos 1203, 41071 Seville, Spain.
Abstract:
Glyoxal bis-hydrazone derived from (S,S)-1-amino-2,5-diphenylpyrrolidine behaves as an excellent ligand for phosphine-free, asymmetric Suzuki-Miyaura cross couplings, thereby affording a variety of enantiomerically enriched biaryls with different substitution patterns. The high catalytic activity of the [PdCl2(bis-hydrazone)] complex allows reactions to be performed at room temperature, affording products with excellent enantioselectivities in all cases.
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