Analytical methodologies for the determination of sertraline

Area of Science:

• Pharmacology
• Analytical Chemistry
• Environmental Science

Background:

• Sertraline is a selective serotonin reuptake inhibitor (SSRI) antidepressant.
• It is effective in treating major depression, obsessive compulsive disorder, panic disorder, eating disorders, premenstrual dysphoric disorder, and post-traumatic stress disorder.
• Various analytical methods exist for sertraline determination in diverse matrices.

Purpose of the Study:

• To systematically review analytical techniques for sertraline determination.
• To cover the period from 1987 to 2008.
• To provide a comprehensive survey of methods applicable to pharmaceutical, biological, and environmental samples.

Main Methods:

• Literature search of analytical techniques for sertraline.
• Review of methods published between 1987 and 2008.
• Categorization of methods based on sample type (pharmaceuticals, biological, environmental).

Main Results:

• A range of analytical techniques have been developed and applied for sertraline quantification.
• Methods vary in sensitivity, specificity, and applicability to different sample types.
• The review consolidates information on established and emerging analytical approaches.

Conclusions:

• Analytical methodologies for sertraline determination are diverse and have evolved over time.
• Accurate determination of sertraline is crucial for therapeutic drug monitoring, pharmacokinetic studies, and environmental assessment.
• This review serves as a valuable resource for researchers and practitioners in selecting appropriate analytical methods.