Related Experiment Video
Updated: Jun 28, 2026

07:27
Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
Published on: December 18, 2012
Serologic screening for herpes simplex virus among university students: a pilot study
Hayley Mark1, Joy P Nanda, Alain Joffe
1The Johns Hopkins School of Nursing, Baltimore, MD 21205, USA. hmark1@son.jhmi.edu
Journal of American College Health : J of ACH
|November 5, 2008
Summary
Implementing herpes simplex virus 2 (HSV-2) testing in universities is complex. Studies show low test reliability and potential negative psychological impacts on students, requiring significant support resources.
Area of Science:
- Infectious Diseases
- Public Health
- Psychology
Background:
- Herpes Simplex Virus 2 (HSV-2) is a common sexually transmitted infection.
- University students represent a population where HSV-2 screening may be considered.
- Assessing the feasibility and impact of HSV-2 testing in this demographic is crucial.
Purpose of the Study:
- To evaluate the practicality of serologic testing for HSV-2 in a university student population.
- To determine the psychosocial effects of receiving an HSV-2 diagnosis among students.
- To identify resource needs for supporting students diagnosed with HSV-2.
Main Methods:
- A convenience sample of 100 university students (aged 18-39) without prior genital herpes history were recruited.
- Participants underwent HSV-2 antibody testing using Focus ELISA and Western Blot assays.
- Psychological functioning was assessed via questionnaires, with a subset completing a 3-month follow-up.
Main Results:
- The study identified low reliability of HSV-2 testing within the student population.
- Positive HSV-2 test results were associated with a potential decline in psychological well-being.
- Significant resources are necessary to provide adequate support for students receiving positive HSV-2 diagnoses.
Conclusions:
- Consideration of test performance is essential before implementing HSV-2 screening programs in universities.
- The potential psychological impact on students must be evaluated.
- Adequate counseling and support resources are critical for students with positive HSV-2 diagnoses.
Related Concept Videos
Genital Herpes
Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
Herpes
Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...

