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Related Concept Videos

Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a membrane...
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Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
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Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
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Antibody Actions

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Related Experiment Video

Updated: Jun 28, 2026

Measuring Phagocytosis of Aspergillus fumigatus Conidia by Human Leukocytes using Flow Cytometry
09:43

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Published on: December 7, 2019

Aspergillus conidia activate the complement by the mannan-binding lectin C2 bypass mechanism.

Chantal Dumestre-Pérard1, Bertrand Lamy, Delphine Aldebert

  • 1Laboratoire Adaptation et Pathogénie des Micro-organismes, Université Joseph Fourier, Grenoble 1, BP 170, Grenoble, France. Chantal.Dumestre@ujf-grenoble.fr

Journal of Immunology (Baltimore, Md. : 1950)
|November 5, 2008
PubMed
Summary

Mannan-binding lectin (MBL) directly supports complement C3 activation via a C2 bypass mechanism, enhancing innate immunity against Aspergillus fungal infections. This finding is crucial for understanding host defense in invasive aspergillosis.

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Last Updated: Jun 28, 2026

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09:43

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Published on: December 7, 2019

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Assessing Anti-fungal Activity of Isolated Alveolar Macrophages by Confocal Microscopy
09:04

Assessing Anti-fungal Activity of Isolated Alveolar Macrophages by Confocal Microscopy

Published on: July 9, 2014

Area of Science:

  • Immunology
  • Microbiology
  • Infectious Diseases

Background:

  • Innate immunity is critical for defense against invasive aspergillosis.
  • Mannan-binding lectin (MBL) is a key component of the innate immune system.
  • The role of MBL in complement activation against Aspergillus remains to be fully elucidated.

Purpose of the Study:

  • To investigate the role of MBL in complement activation against Aspergillus conidia.
  • To determine if MBL can initiate complement pathways against fungal infections.
  • To compare complement activation by clinical and environmental Aspergillus strains.

Main Methods:

  • In vitro studies using 29 Aspergillus conidia strains from five species.
  • Incubation with human normal serum and MBL-deficient serum.
  • Reconstitution experiments with MBL/MASPs complexes.
  • Analysis of complement activation pathways (classical, lectin, alternative).

Main Results:

  • Aspergillus conidia activated the alternative complement pathway but not classical or lectin pathways.
  • MBL directly supports C3 activation through a C2 bypass mechanism.
  • Clinical Aspergillus strains showed stronger alternative pathway activation than environmental strains.

Conclusions:

  • MBL plays a direct role in complement activation against Aspergillus via a C2 bypass mechanism.
  • This MBL-mediated complement activation contributes to innate immunity against invasive aspergillosis.
  • Clinical Aspergillus isolates exhibit enhanced complement activation, suggesting potential virulence factors.