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Updated: Aug 2, 2026

Measuring the 50% Haemolytic Complement (CH50) Activity of Serum
08:26

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Complement activation during bypass in acquired C1 esterase inhibitor deficiency

R S Bonser1, J Dave, J Morgan

  • 1Brompton Hospital, London, United Kingdom.

The Annals of Thoracic Surgery
|September 1, 1991
PubMed

Serial complement estimations during cardiopulmonary bypass are reported in a patient with acquired C1 esterase inhibitor deficiency. Although the extent of classic and alternative pathway activation appeared appropriate, exaggerated common pathway activation with massive increase in the C3d:C3 ratio occurred. A fatal hemostatic disorder, pulmonary edema, and circulatory collapse ensued despite prophylaxis and therapy.

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